A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
FIBRINOGEN
MessageCoagulation
Test Code
LAB314
Alias/See Also
FIBR
CPT Codes
85384
Preferred Specimen
2.7 ml. whole blood (blue top tube, citrate) **TUBE MUST BE FULL**
Minimum Volume
2.7 mL whole blood filled to the designated line on specimen container (blue top tube, citrate)
Other Acceptable Specimens
1.8mL Low Volume blue top tube, citrated
Instructions
FIBR: testing must be completed within 4 hours of collection.
LAB: Centrifuge in validated Platelet Poor Plasma Centrifuges only
LAB: Centrifuge in validated Platelet Poor Plasma Centrifuges only
Transport Container
Processed Platelet Poor Plasma, preferably frozen
Transport Temperature
Processed Platelet Poor Plasma:
Room Temp – 4 hours
Refrigerated – 4 hours
Frozen – 2 weeks
Room Temp – 4 hours
Refrigerated – 4 hours
Frozen – 2 weeks
Specimen Stability
Whole Blood: Ambient 4 hours
Plasma separated from whole blood 2-8°C 4 hours
Plasma separated from whole blood -20°C 2 weeks
Plasma separated from whole blood -70°C 6 months
Plasma separated from whole blood 2-8°C 4 hours
Plasma separated from whole blood -20°C 2 weeks
Plasma separated from whole blood -70°C 6 months
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Underfilled tube - Quantity not Sufficient (QNS)
Clotted specimen
Clotted specimen
Methodology
Fibrinogen is a plasma protein that is converted from a soluble protein to an insoluble polymer by the action of thrombin, resulting in the formation of a fibrin clot. Fibrinogen in the diluted test sample is converted to fibrin by the addition of an excess amount of thrombin. The resulting clotting time value is measured. The log of the clotting time value is inversely proportional to the log of the fibrinogen concentration. A fibrinogen reference curve is plotted from the clotting time results of the known referenced plasma dilutions having different fibrinogen values. The concentration of fibrinogen in patient plasma samples is determined by comparing clotting time values to the reference curve.
Report Available
Same Day
Limitations
Hemoglobin up to 375 mg/dL
Bilirubin up to 23 mg/dL
Triglycerides up to 880 mg/dL
Heparin up to 2 U/mL
Bilirubin up to 23 mg/dL
Triglycerides up to 880 mg/dL
Heparin up to 2 U/mL
Reference Range
200-393 mg/dL
Critical Value: <100 mg/dL
Critical Value: <100 mg/dL
Clinical Significance
Fibrinogen is made in your liver and helps your blood clot. Low fibrinogen may make it difficult for your blood to clot.
Performing Laboratory
HHN/HHI