Apolipoprotein Evaluation

LAB5210247

7018

Apolipoprotein A1
Apolipoprotein B
Apolipoprotein B/A1 Ratio

1 mL serum

0.5 mL

Room temperature

Room temperature: 7 days
Refrigerated: 7 days
Frozen: 30 days

Grossly lipemic

Set up: Mon-Sat; Report available: 1-2 days

Apolipoprotein A1

Male	≥115 mg/dL
Female	≥125 mg/dL
Risk Category	Male	Female
Optimal	≥115 mg/dL	≥125 mg/dL
High	<115 mg/dL	<125 mg/dL

Cardiovascular event risk category cut points (optimal, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.

Apolipoprotein B	<90 mg/dL
Risk Category
Optimal	<90 mg/dL
Moderate	90-129 mg/dL
High	≥130 mg/dL

A desirable treatment target may be <80 mg/dL or lower depending on the risk category of the patient including patients on lipid lowering therapies, patients with ASCVD, diabetes with >1 risk factors, Stage 3 or greater CKD with albuminuria, or heterozygous familial hypercholesterolemia. ApoB relative risk category cut points are based on AACE/ACE and ACC/AHA recommendations (Grundy SM, et al. 2019. doi:10.1016/j.jacc.2018.11.002; Handelsman Y, et al. 2020. doi:10.4158/CS-2020-0490).

Apolipoprotein B/A1 Ratio

Male	<0.77
Female	<0.63
Risk Category	Male	Female
Optimal	<0.77	<0.63
Moderate	0.77-0.95	0.63-0.78
High	>0.95	>0.78

Cardiovascular event risk category cut points (optimal, moderate, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188-205.

Apolipoprotein A1 is the primary protein associated with HDL cholesterol. Like HDL cholesterol, increased concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B-100 is the primary protein associated with LDL cholesterol and other lipid particles. Like LDL cholesterol, increased concentrations are associated with increased risk of cardiovascular disease. The ratio of these two apolipoproteins correlates with risk of cardiovascular disease.