Cancer antigen 15-3

Message

Chemistry

Test Code

LAB776

CPT Codes
86300

Preferred Specimen

1 mL serum

Minimum Volume

0.5 mL

Specimen Stability

2-8⁰ C ≤ 7 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross lipemia: Reject

Methodology
Immunoassay (IA)

Setup Schedule

Everyday

Report Available

Same day

Reference Range

<35 U/mL

Clinical Significance

The VITROS CA 15-3 test utilizes two monoclonal antibodies (115D8 as capture and DF3 as conjugate), which react with DF3 defined antigen, expressed by human breast carcinoma cells. The 115D8 antibody was raised against antigens of human milk fat globule membranes. 4‑ 7 The DF3 antibody was prepared against a membrane-enriched fraction of a human breast carcinoma. 8, 9 The results of studies indicate that the concentration of the DF3 defined antigen is frequently elevated in the serum of patients with breast cancer as well as with other malignancies, such as lung cancer, and in some nonmalignant disorders.

Performing Laboratory
HHN Laboratory
HHI Laboratory

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.