Autoimmune Dementia Profile, CSF

Message

Sendout, Mayo test code: DMC2

Test Code

LAB1238033

Alias/See Also

AMPA-R Ab CBA
Amphiphysin Ab
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
CASPR2-IgG
Cognitive decline
Cognitive impairment
Contactin-Associated Protein-Like-2 (CASPR2)-IgG
CRMP-5-IgG
DEMEC
DPPX
dipeptidyl aminopeptidase-like protein 6
GABA-B-R Ab CBA
Glutamic Acid Decarboxylase (GAD65)
LGI1-IgG
NMDA-R Ab CBA
metabotropic glutamate receptor 1
mGluR1
Purkinje Cell Cytoplasmic Ab Type 2
GFAP
IgLON5
NIF
Leucine-Rich Glioma Inactivated Protein-1 IgG
Purkinje Cell Cytoplasmic Ab Type Tr
Neurochondrin Antibody (NCDN-2)
Phosphodiesterase 10A (PDE10A)
Tripartite Motif-Containing Protein 46 (TRIM46)

CPT Codes
86255 x 21, 86341

Preferred Specimen

Collection vial #1. 4 mL CSF

Minimum Volume

2 mL

Other Acceptable Specimens

Any collection vial

Transport Container

Sterile vial

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated (preferred): 28 days
Ambient: 72 hours
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis, gross lipemia, gross icterus

Methodology
Indirect immunofluorescence Assay (IFA), Cell Binding Assay (CBA), Immunoblot (IB), Western Blot (WB), Radioimmunoassay (RIA)

Setup Schedule

Monday through Sunday; Reflex tests: Varies

Report Available

8 to 12 days

Reference Range

Included with report

Clinical Significance

Investigating new onset dementia and cognitive impairment plus 1 or more of the following accompaniments using cerebrospinal fluid specimens:

-Rapid onset and progression
-Fluctuating course
-Psychiatric accompaniments (psychosis, hallucinations)
-Movement disorder (myoclonus, tremor, dyskinesias)
-Headache
-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)
-Smoking history (20 or more pack-years) or other cancer risk factors
-History of cancer
-Inflammatory cerebrospinal fluid
-Neuroimaging findings atypical for degenerative etiology

Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota

Additional Information
Dementia, Autoimmune/Paraneoplastic Evaluation, Spinal Fluid

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.