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Pancreatic Polypeptide
MessageSendouts, Mayo test code: HPP
Test Code
LAB5211261
CPT Codes
83519
Preferred Specimen
3 mL plasma from a lavendar EDTA tube
Patient Preparation
Fasting (8 hours)
Minimum Volume
0.35 mL
Instructions
1. Place specimen on wet ice and keep cold at all times following collection.
2. Centrifuge (refrigerated centrifuge is not required) and aliquot plasma into a plastic vial. Freeze immediately.
2. Centrifuge (refrigerated centrifuge is not required) and aliquot plasma into a plastic vial. Freeze immediately.
Transport Container
Plastic vial
Transport Temperature
Frozen
Specimen Stability
Frozen (preferred): 90 days
Refrigerated: 14 days
Ambient: 7 days
Refrigerated: 14 days
Ambient: 7 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis
Gross lipemia
Gross lipemia
Methodology
Radioimmunoassay (RIA)
FDA Status
Approved
Setup Schedule
Monday, Wednesday
Report Available
4 to 8 days
Limitations
Pancreatic polypeptide (PP) normal values increase with age (approximately 20 pg/mL per decade).
Nonfasting state results in falsely elevated values.
The sham feeding test is invalid if food is swallowed. Ingestion of food typically results in a significant and prolonged PP increase over baseline (typically >200 pg/mL).
This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.
Nonfasting state results in falsely elevated values.
The sham feeding test is invalid if food is swallowed. Ingestion of food typically results in a significant and prolonged PP increase over baseline (typically >200 pg/mL).
This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. A recommended time period before collection cannot be made because it will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held and assayed after the radioactivity has sufficiently decayed. This will result in a test delay.
Reference Range
Included with report
Clinical Significance
Detecting pancreatic endocrine tumors
Assessing vagal nerve function after meal or sham feeding
Assessing vagal nerve function after meal or sham feeding
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Pancreatic Polypeptide,
