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Mutated Citrullinated Vimentin (MCV) Antibody
Test CodeLAB1238015
Quest Code
13238
CPT Codes
83520
Preferred Specimen
1 mL serum
Minimum Volume
0.5 mL
Instructions
Draw whole blood using a red-top tube or serum separator tube (SST)
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 7 days
Refrigerated: 14 days
Frozen: 6 months
Refrigerated: 14 days
Frozen: 6 months
Methodology
Enzyme Linked Immunosorbent Assay (ELISA)
Setup Schedule
A.M. Sets up 7 days a week.
Reference Range
<20 U/mL
Clinical Significance
Anti-mutated citrullinated vimentin (MCV) antibody is one of several specific anti-citrullinated protein antibodies which may be used as a second-line marker of rheumatoid arthritis (RA), in addition to rheumatoid factor and anti-cyclic citrullinated peptide (CCP). MCV antibody is less specific than CCP but has a slightly higher sensitivity and the addition of MCV to CCP adds 5-10% sensitivity for the diagnosis of RA. MCV antibody positivity is also associated with more severe disease and greater radiologic progression.
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042