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Drugs of Abuse, Methadone, Confirmation, Urine
MessageSendout, Mayo test code: MTDNU
Test Code
LAB234020
Alias/See Also
Dolophine (Methadone)
Methadone (Dolophine)
EDDP
2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine
MTDNU
Methadone (Dolophine)
EDDP
2-Ethylidene-1,5-Dimethyl-3,3-Diphenylpyrrolidine
MTDNU
CPT Codes
80358, G0480 (if appropriate)
Preferred Specimen
10 mL random urine collection
Minimum Volume
2.5 mL
Instructions
1. Collect a random urine specimen.
2. No preservative.
2. No preservative.
Transport Container
Plastic urine container
Transport Temperature
Refrigerated
Specimen Stability
Refrigerated (preferred): 28 days
Frozen: 28 days
Ambient: 14 days
Frozen: 28 days
Ambient: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis: OK
Gross icterus: OK
Gross icterus: OK
Methodology
Gas Chromatography Mass Spectrometry (GC-MS) Confirmation with Quantitation
FDA Status
Approved
Setup Schedule
Tuesday, Thursday
Report Available
3-7 days
Limitations
Urine pH has a considerable effect on the ability to detect methadone, thus 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine is preferable for urine measurements.
Urine concentrations of methadone show very poor correlation to serum levels or the amount of drug administered.
Urine concentrations of methadone show very poor correlation to serum levels or the amount of drug administered.
Reference Range
Included with report
Clinical Significance
Monitoring for compliance of methadone treatment for analgesia or drug rehabilitation
Assessing compliance with rehabilitation programs by urine measurement of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
Assessing compliance with rehabilitation programs by urine measurement of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Methadone Confirmation, Random, Urine
