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Iron, Liver Tissue
MessageSendout, Mayo test code: FET
Test Code
LAB3
Alias/See Also
Fe (Iron)
Hemochromatosis
Hepatic Iron Concentration
Hepatic Iron Index
Iron (Fe)
Iron, Tissue Liver
Metals, Tissue
Quantitative Iron
Total Iron, Liver Tissue
FET
Hemochromatosis
Hepatic Iron Concentration
Hepatic Iron Index
Iron (Fe)
Iron, Tissue Liver
Metals, Tissue
Quantitative Iron
Total Iron, Liver Tissue
FET
CPT Codes
83540
Preferred Specimen
2 mg of liver tissue in a Mayo metal-free specimen vial
Minimum Volume
2 cm (22-gauge needle)
1 cm (18-gauge needle)
2 mm x 2 mm (punch) 0.3 mg by dry weight
1 cm (18-gauge needle)
2 mm x 2 mm (punch) 0.3 mg by dry weight
Other Acceptable Specimens
Paraffin block, if not more than 1 or 2 cuts have been made to it for slides
Instructions
1. Two mg of liver tissue is required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length.
2. Any specimen vial other than a Mayo metal-free vial used should be plastic, leached with 10% nitric acid for 2 days, rinsed with redistilled water, and dried in clean air.
Additional Information: Paraffin blocks will be returned 3 days after analysis is complete.
2. Any specimen vial other than a Mayo metal-free vial used should be plastic, leached with 10% nitric acid for 2 days, rinsed with redistilled water, and dried in clean air.
Additional Information: Paraffin blocks will be returned 3 days after analysis is complete.
Transport Temperature
Refrigerated
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.
Methodology
Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
FDA Status
Approved
Setup Schedule
Monday, Thursday
Report Available
3-6 days
Limitations
Formalin-fixed, paraffin-embedded tissue can be used when histologic examination (including iron stains) is requested in addition to the hepatic iron concentration and calculated hepatic iron index; however, fresh or frozen tissue is preferred.
Paraffin blocks from which many slides have been previously cut often appear to contain sufficient quantity of tissue, however, the specimen is often very thin and less than 2 mg in weight.
Paraffin blocks from which many slides have been previously cut often appear to contain sufficient quantity of tissue, however, the specimen is often very thin and less than 2 mg in weight.
Reference Range
Included with report
Clinical Significance
Diagnosis of hemochromatosis using liver tissue specimens
Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota
Additional Information
Iron, Liver Tissue
