Myelin Oligodendrocyte Glycoprotein FACS Assay

Message

Sendout, Mayo test code: MOGFS

Test Code

LAB5211541

Alias/See Also

MOG-IgG
MOG
Optic Neuritis Antibody
Transverse Myelitis Antibody
Vision Loss Antibody
ADEM antibody
NMO antibody
Fluorescence0Activated Cell Sorting
MOGFS

CPT Codes
86363

Includes

When the results of this assay require further evaluation, the reflex titer test will be performed at an additional charge.

Preferred Specimen

2 mL serum from a red tube

Patient Preparation
For optimal antibody detection, specimen collection should occur prior to initiation of immunosuppressant medication.

Minimum Volume

1 mL

Other Acceptable Specimens

Serum gel tube

Instructions

Centrifuge and aliquot serum into a plastic vial.

Transport Container

Plastic vial

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated (preferred): 28 days
Frozen: 28 days
Ambient: 72 hours

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Gross hemolysis: Reject
Gross lipemia: Reject
Gross icterus: Reject

Methodology
Flow Cytometry

FDA Status
Approved

Setup Schedule

Monday, Tuesday, Thursday

Report Available

5-8 days

Limitations

Myelin oligodendrocyte glycoprotein (MOG)-IgG, specifically MOG-IgG1, may drop below detectable levels in setting of therapies for acute attack (IV methylprednisolone or plasmapheresis) or attack prevention (immunosuppressants).

Reference Range

Included with report

Clinical Significance

Diagnosis of inflammatory demyelinating diseases (IDD) with similar phenotype to neuromyelitis optica (NMO) spectrum disorder (NMOSD), including optic neuritis (single or bilateral) and transverse myelitis

Diagnosis of autoimmune myelin oligodendrocyte glycoprotein (MOG)-opathy

Diagnosis of NMO

Distinguishing NMOSD, acute disseminated encephalomyelitis (ADEM), optic neuritis, and transverse myelitis from multiple sclerosis early in the course of disease

Diagnosis of ADEM

Prediction of a relapsing disease course

Performing Laboratory
Mayo Clinic Laboratories, Rochester, Minnesota

Additional Information
Myelin Oligodendrocyte Glycoprotein (MOG-IgG1) Fluorescence-Activated Cell Sorting (FACS) Assay, Serum

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.