A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Actin (Smooth Muscle) Antibody (IgG)
Test Code15043
CPT Codes
86015
Preferred Specimen
0.5 mL serum
Minimum Volume
0.25 mL
Transport Container
Transport tube
Transport Temperature
Room temperature
Specimen Stability
Room temperature: 14 days
Refrigerated: 14 days
Frozen: 30 days
Refrigerated: 14 days
Frozen: 30 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis • Lipemia • Microbially contaminated serum • Specimens containing heavy, visible particulate
Methodology
Enzyme Linked Immunosorbent Immunoassay (ELISA)
Setup Schedule
Mon-fri
Reference Range
<20 U | Negative |
≥20 U |
Positive |
Antibodies recognizing actin are the main component of smooth muscle antibodies associated with autoimmune liver disease. Actin antibodies are found in approximately 75% of patients with autoimmune hepatitis (AIH) type 1, approximately 65% of patients with autoimmune cholangitis, approximately 30% of patients with primary biliary cirrhosis, and approximately 2% of healthy people. High values are closely correlated with AIH type 1.
Clinical Significance
Actin is the major antigen to which smooth muscle antibodies react in autoimmune hepatitis. F-Actin IGG antibodies are found in 52-85% of patients with Autoimmune Hepatitis (AIH) or chronic active hepatitis and in 22% of patients with Primary Biliary Cirrhosis (PBC). Anti-Actin antibodies have been reported in 3-18% of sera from normal healthy controls.
Performing Laboratory
Quest Diagnostics Nichols Institute-Chantilly VA |
14225 Newbrook Drive |
Chantilly, VA 20151-2228 |