| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
FISH, TCL1, 14q32.1
Test Code90512
CPT Codes
88271 (x2), 88275
Preferred Specimen
3 mL bone marrow or 5 mL whole blood collected in a sodium heparin (green-top) tube
Minimum Volume
1 mL bone marrow • 3 mL whole blood
Other Acceptable Specimens
Bone marrow collected in: Transport medium, sodium heparin (royal blue-top) tube, or sodium heparin lead-free (tan-top) tube • Whole blood collected in: Sodium heparin (royal blue-top) tube or sodium heparin lead-free (tan-top) tube • 5x5 mm tumor tissue in formalin-fixed, paraffin-embedded tissue block
Transport Container
Sodium heparin (green-top) tube
Transport Temperature
Room temperature
Specimen Stability
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Fluorescence in situ Hybridization (FISH)
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Daily
Clinical Significance
The proto-oncogene TCL1 located at 14q32.1 is overexpressed in a variety of lymphoid neoplasms, including T-cell prolymphocytic leukemia (T-PLL), T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), Epstein-Barr virus (EBV)-infected B-cell lymphomas and AIDS-related lymphomas. The overexpression of TCL1 usually results from juxtaposition to a T-cell receptor locus via a translocation or inversion.
Performing Laboratory
| Quest Diagnostics Nichols Institute-Chantilly VA |
| 14225 Newbrook Drive |
| Chantilly, VA 20151-2228 |
