HER2 (Other) - with Gastric Scoring

Message

Probes: HER2 (17q11.2-q12) | Centromere 17 (Cen 17). Disease(s): Endometrial cancer, salivary duct carcinoma, ovarian cancer, serous carcinomas, and other various tumor types

Test Code

LAB6256

Alias/See Also

HER2 neu

CPT Codes
88374x1

Preferred Specimen

Pathology Report: For global HER2 FISH cases we require a copy of the HER2 IHC pathology report (if it is not available to us in NeoLINK™). For HER2 (Other) with Breast Scoring, the HER2 IHC slide may also be required for interpretation of results. Client Services will call your office or lab for missing IHC reports or to request slides. Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only. Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns.Circle H&E for tech only.

Instructions

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Methodology
FISH

Report Available

3-5 days

Clinical Significance

HER2, a member of the epidermal growth factor receptor family, is a transmembrane protein with tyrosine kinase activity. Gene amplification and protein overexpression of HER2 have been found in a variety of tumors. This test provides HER2 amplification status to aid in determining anti-HER2 targeted therapies for patients. Scoring is performed using the following: HER2 (Other) with Gastric scoring uses the 2016 CAP/ASCP/ASCO consensus guidelines for gastric/gastroesophageal adenocarcinoma for HER2 evaluation.

Performing Laboratory
Neogenomics Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.