HER2 (Other) - with Breast Scoring

Probes: HER2 (17q11.2-q12) | Centromere 17 (Cen 17). Disease(s): Endometrial cancer, salivary duct carcinoma, ovarian cancer, serous carcinomas, and other various tumor types

LAB6255

HER2 neu

Pathology Report: For global HER2 FISH cases we require a copy of the HER2 IHC pathology report (if it is not available to us in NeoLINK™). For HER2 (Other) with Breast Scoring, the HER2 IHC slide may also be required for interpretation of results. Client Services will call your office or lab for missing IHC reports or to request slides. Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only. Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns.Circle H&E for tech only.

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

3-5 days

HER2, a member of the epidermal growth factor receptor family, is a transmembrane protein with tyrosine kinase activity. Gene amplification and protein overexpression of HER2 have been found in a variety of tumors. This test provides HER2 amplification status to aid in determining anti-HER2 targeted therapies for patients. Scoring is performed using the following: HER2 (Other) with Breast scoring uses the 2018 CAP/ASCO guidelines for breast cancer for HER2 evaluation. Breast scoring is recommended for indications such as endometrium cancer, salivary duct carcinoma, serous carcinoma, and ovarian cancer as well as other clinical indications without consensus guidelines.