HER2 Gastric/GEA FISH

Message

Probes: HER2 (17q11.2-q12) | Centromere 17 (Cen 17). Disease(s): Gastric cancer, Gastroesophageal Adenocarcinoma, Gastroesophageal junction (GEJ) cancer

Test Code

LAB6253

Alias/See Also

HER2 neu

CPT Codes
88374x1

Preferred Specimen

Pathology Report: For global HER2 FISH cases we require a copy of the HER2 IHC pathology report (if it is not available to us in NeoLINK™). Client Services will call your office or lab for missing IHC reports. Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only.Cut Slides: H&E slide (required) plus 2 unstained slides cut at 4 microns. Circle H&E for tech only.

Instructions

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Methodology
FISH

Report Available

3-5 days

Clinical Significance

HER2, a member of the epidermal growth factor receptor family, is a transmembrane protein with tyrosine kinase activity. Gene amplification and protein overexpression of HER2 have been found in a variety of tumors. This test provides HER2 amplification status to aid in determining anti-HER2 targeted therapies for patients with gastric cancer. Scoring for HER2 is performed according to 2016 CAP/ASCP/ACSO consensus guidelines for gastric/gastroesophageal adenocarcinoma.

Performing Laboratory
Neogenomics Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.