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FLT3 Mutation Analysis
MessageDetection of internal tandem duplication and exon 20 tyrosine kinase domain (TKD) mutations using fragment-length analysis and PCR. Positive results identify presence of TKD mutations or report ITD results quantitatively as allelic ratio
Test Code
LAB6007
Alias/See Also
FLT3, FLT3 TKD, FLT3 ITD
CPT Codes
81245x1,81246x1
Preferred Specimen
Peripheral blood: 5 mL in EDTA tube. Bone marrow: 2 mL in EDTA tube. FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Methodology
Molecular
Report Available
5 days
Clinical Significance
Testing for FLT3 and other gene mutations in AML patients with intermediate-risk cytogenetic abnormalities can improve risk stratification. The presence of an FLT3 mutation in a patient with AML implies aggressive disease.
Performing Laboratory
Neogenomics Laboratories
