|
|
| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
ABL1 Kinase Domain Mutation Analysis
MessageRT-PCR and sequencing of the BCR-ABL1 fusion transcript for qualitative detection of mutations associated with resistance to Gleevec (imatinib) and other tyrosine kinase inhibitors. Analysis includes detection of all mutations recommended by guidelines, including the common T315I, Y253H, E255K/V, F359V/C/I, F317L/V/I/C, T315A, and V299L.
Test Code
LAB6004
Alias/See Also
| ABL1 Kinase |
CPT Codes
81770X1
Preferred Specimen
Peripheral blood: 5 mL in EDTA tube. Bone marrow: 2 mL in EDTA tube.
Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <7 days old preferred.
Methodology
Molecular
Report Available
10 days
Clinical Significance
Testing is recommended in CML with poor initial response to Gleevec (imatinib), relapse, or progression to accelerated/blast phase. Presence and identity of mutation may direct management to alternative drugs or stem cell transplant.
Performing Laboratory
Neogenomics Laboratories
