JAK2 V617F Mutation Analysis Molecular

Message

Qualitative detection of the V617F mutation. The rare mutation V617I is also detected. Testing is performed on plasma for increased sensitivity whenever possible. V617F testing may be ordered separately, concurrently with full exon 12-13 sequencing, with reflex to exon 12-13 sequencing, or as part of the MPN JAK2 V617F with Sequential Reflex to JAK2 Exon 12-13, CALR, and MPL

Test Code

LAB4680

Alias/See Also

JAK2 Mutation Analysis

CPT Codes
81270x1

Preferred Specimen

Peripheral Blood: 5 mL EDTA tube •Bone Marrow: 2 mL EDTA tube

Instructions

Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <7 days old preferred.

Methodology

Molecular

Report Available

7 days

Clinical Significance

The JAK2 V617F mutation is present in approximately 90% of polycythemia vera (PV) cases and approximately 40% of primary myelofibrosis (PMF) or essential thrombocythemia (ET). Mutation analysis helps differentiate reactive conditions from myeloproliferative neoplasms (MPNs).

Performing Laboratory

Neogenomics Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.