17 Hydroxypregnenolone

Test Code

LAB6506

Quest Code

8352X

CPT Codes
84143

Preferred Specimen

2 mL (0.4 mL minimum) serum collected in a red-top
tube (no gel)

Transport temperature: Refrigerated

Minimum Volume

0.4 mL

Specimen Stability

Room temperature: 24 hours
Refrigerated: 5 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Received room temperature; serum separator tube; gross
hemolysis; grossly lipemic; grossly icteric

Methodology
Chromatography/Mass Spectrometry

Setup Schedule

Set up: Tues, Fri p.m.; Report available: 3-5 days

Limitations

Infants with 21-hydroxylase deficiency may present with non-elevated results.

Reference Range

Adult Males

≤700 ng/dL

Adult Females, Pre-Menopausal

Mid Follicular	38-378 ng/dL
Surge	33-583 ng/dL
Mid Luteal	70-470 ng/dL

Pediatric Male and Female

<30 days	≤3013 ng/dL
1-11 months	≤869 ng/dL
1 year	≤557 ng/dL
2 years	≤487 ng/dL
3 years	≤541 ng/dL
4 years	≤561 ng/dL
5 years	≤564 ng/dL
6 years	≤561 ng/dL
7 years	≤549 ng/dL
8 years	≤569 ng/dL
9 years	≤590 ng/dL
10 years	≤594 ng/dL
11 years	≤629 ng/dL
12 years	≤666 ng/dL
13 years	≤678 ng/dL
14 years	≤706 ng/dL
15 years	≤735 ng/dL
16 years	≤739 ng/dL
17 years	≤756 ng/dL

Clinical Significance

17-Hydroxypregnenolone is useful in the diagnosis of 3-Beta-Hydroxylase enzyme deficiency, a rare cause of congenital adrenal hyperplasia, and 17-Hydroxylase (P450c17) enzyme deficiency.

Performing Laboratory
Quest Diagnostics Nichols SJC

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.