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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
PROTEIN S PANEL
Test Code11343X
CPT Codes
PROF
Includes
Protein S Activity
Protein S Antigen, Free
Protein S Antigen, Total
C4 Binding Protein, Plasma
Protein S Antigen, Free
Protein S Antigen, Total
C4 Binding Protein, Plasma
Preferred Specimen
4 mL 3.2% Sodium Citrate (lt. blue-top) plasma
in 4 - 1.0 mL frozen aliquot tubes.
3.8% Sodium Citrate is unacceptable.
Draw blood in light blue-top tube containing
3.2% sodium citrate, mix gently by inverting
3-4 times. Centrifuge 15 minutes at 1500 g
within 1 hour of collection. Using a plastic pipette,
remove plasma, taking care to avoid the
WBC/platelet buffy layer and place into a plastic vial.
Centrifuge this plastic vial a second time and
transfer platelet-poor plasma into 2 new
plastic vials. Mark tubes as citrated plasma.
Freeze immediately; store and transport frozen.
When multiple frozen plasma tests are requested,
please submit separate frozen aliquots.
Label each aliquot tube as citrated plasma.
in 4 - 1.0 mL frozen aliquot tubes.
3.8% Sodium Citrate is unacceptable.
Draw blood in light blue-top tube containing
3.2% sodium citrate, mix gently by inverting
3-4 times. Centrifuge 15 minutes at 1500 g
within 1 hour of collection. Using a plastic pipette,
remove plasma, taking care to avoid the
WBC/platelet buffy layer and place into a plastic vial.
Centrifuge this plastic vial a second time and
transfer platelet-poor plasma into 2 new
plastic vials. Mark tubes as citrated plasma.
Freeze immediately; store and transport frozen.
When multiple frozen plasma tests are requested,
please submit separate frozen aliquots.
Label each aliquot tube as citrated plasma.
Minimum Volume
0.5 mL X 4
Specimen Stability
Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 14 days
Refrigerated: Unacceptable
Frozen: 14 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Received not frozen, hemolyzed
Methodology
Clot Detection • Microlatex Particle Mediated Immunoassay • Enzyme Immunoassay • Radial Immunodiffusion
Setup Schedule
See individual assays
Reference Range
| Protein S Activity | |
| Male | 70-150 % normal |
| Female | 60-140 % normal |
| Protein S Antigen, Free | |
| Male | 57-171 % normal |
| Female | 50-147 % normal |
| Protein S Antigen, Total | 70-140 % normal |
| C4 Binding Protein | 305-695 mg/L |
Clinical Significance
Provides for distinguishing Type I, II, and III Protein S deficiency which may help in appropriate diagnosis, treatment and genetic counseling.
Performing Laboratory
Quest Diagnostics Nichols Chantilly
