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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
THYROGLOBULIN
Test CodeLAB3793
Quest Code
30278X
CPT Codes
PROF
Includes
Thyroglobulin Antibodies and Quantitative Thyroglobulin
Preferred Specimen
2 mL serum
Dietary supplements containing biotin may interfere in
assays and may skew results to be either falsely high
or falsely low. For patients receiving the recommended
daily doses of biotin, draw samples at least 8 hours
following the last biotin supplementation. For patients
on mega-doses of biotin supplements, draw samples
at least 72 hours following the last biotin
supplementation.
Dietary supplements containing biotin may interfere in
assays and may skew results to be either falsely high
or falsely low. For patients receiving the recommended
daily doses of biotin, draw samples at least 8 hours
following the last biotin supplementation. For patients
on mega-doses of biotin supplements, draw samples
at least 72 hours following the last biotin
supplementation.
Minimum Volume
1 mL
Specimen Stability
Room temperature: 7 days
Refrigerated: 7 days
Frozen: 28 days
Refrigerated: 7 days
Frozen: 28 days
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Gross hemolysis; Gross lipemia
Methodology
Immunoassay (IA)
Setup Schedule
Set up: Mon,Wed,Fri; Report available 1-4 days
Report Available
1-4 days
Reference Range
See Laboratory Report
Clinical Significance
Thyroglobulin (TG) is a secretory product only of the thyroid gland. The major clinical use of serum TG measurement is to monitor, but not to diagnose, patients with well-differentiated thyroid cancers. The measurement of thyroglobulin, after thyroidectomy and ablation of the thyroid gland, is useful to determine metastasis.
Deficient TG synthesis is observed in infants with goitrous hypo-thyroidism. Most patients with thyroid autoimmune disease have thyroglobulin antibody. With immunometric assays (sandwich assays), TGAB interference typically produces inappropriately low TG results, most likely caused by endogenous TG immune complexes that block one or more of the reagent antibodies from binding endogenous TG.
Deficient TG synthesis is observed in infants with goitrous hypo-thyroidism. Most patients with thyroid autoimmune disease have thyroglobulin antibody. With immunometric assays (sandwich assays), TGAB interference typically produces inappropriately low TG results, most likely caused by endogenous TG immune complexes that block one or more of the reagent antibodies from binding endogenous TG.
Performing Laboratory
Quest Diagnostics HORSHAM
