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TP53 Mutation Analysis
MessageBi-directional sequencing of TP53 exons 4-9.
Test Code
LAB6034
Alias/See Also
TP53 Gene Sequencing
CPT Codes
81405x1
Preferred Specimen
Peripheral blood: 5 mL in EDTA tube. Bone marrow: 2 mL in EDTA tube. FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Methodology
Molecular
Report Available
10 days
Clinical Significance
TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. The TP53 gene encodes the tumor suppressor p53. Germline mutations in TP53 are the cause of Li-Fraumeni Syndrome.
Performing Laboratory
Neogenomics Laboratories
