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TCL1 (14q32.1)
MessageProbes: TCL1 (14q32.1)
Disease(s): mature T-cell leukemia, T-cell prolymphocytic leukemia (T-PLL), adult T-cell leukemia/lymphoma (ATLL)
Disease(s): mature T-cell leukemia, T-cell prolymphocytic leukemia (T-PLL), adult T-cell leukemia/lymphoma (ATLL)
Test Code
LAB6027
Alias/See Also
T-cell leukemia 1
CPT Codes
88377x1 manual or 88374x1 automated.
Preferred Specimen
Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable. Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable. Fresh, Unfixed Tissue: Tissue in RPMI. Fluids: Equal parts RPMI to specimen volume. Paraffin block: Send paraffin block. Also send circled H&E slide for tech-only (required). Cut slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Instructions
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Methodology
FISH
Report Available
4 days for unfixed or FFPE specimens
Clinical Significance
This breakapart probe covers breakpoint regions in the TCL1 (T-cell leukemia) gene cluster on chromosome 14q32 which encompasses TCL1A, TCL1B, and other genes. TCL1 translocations and inversions occur in mature T-cell leukemias including T-cell prolymphocytic leukemia (T-PLL) and adult T-cell leukemia/lymphoma (ATLL). These rearrangements cause gene overexpression due to juxtaposition with TCR-alpha or TCR-beta regulatory elements and contribute to oncogenesis.
Performing Laboratory
Neogenomics Laboratories
