NRAS Mutation Analysis

Message

Bi-directional sequencing of NRAS exons 2 and 3 which includes sites of common activating mutations in codons 12, 13, 59, and 61. Testing is approved for specimens from the state of New York.

Test Code

LAB4126

Alias/See Also

NRAS Gene Sequencing

CPT Codes
81311x1

Preferred Specimen

Peripheral blood: 5 mL in EDTA tube. Bone marrow: 2 mL in EDTA tube. FFPE solid tumor tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.

Instructions

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

Methodology
PCR

Report Available

7 days

Clinical Significance

NRAS is highly homologous with KRAS; both are members of the most frequently mutated family of oncogenes. NRAS Mutations are found in a wide variety of solid tumors, in advanced systemic mastocytosis, and in myeloid neoplasias.

Performing Laboratory
Neogenomics Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.