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Plasma Cell Myeloma FISH Panel
MessageProbes: 1p-, 1q+, iso(1q): CDKN2C (1p32), CKS1B (1q21) | +5, hyperdiploidy (5p15) | +9, hyperdiploidy (9q22) | +15, hyperdiploidy (15q22) | 13q- (13q14, 13q34) | IgH (14q32) | 17p- (TP53 17p13.1, NF1 17q11.2)
Probes may be ordered separately except +5, +9 and +15 which are combined.
Global cases with IgH rearrangement will automatically reflex to the Plasma Cell Myeloma IgH Complex FISH Panel unless client has opted out.
Disease(s): Plasma cell myeloma, multiple myeloma
Note: Plasma cell enrichment will be performed on bone marrow or blood samples unless our client directs us otherwise. (Peripheral blood is not recommended as a screening specimen unless increased plasma cells are seen on blood smear.) Specimens should be received in our laboratory within 72 hours of collection. If enriched samples are insufficient to complete the whole panel, NeoGenomics will prioritize p53 testing unless directed otherwise by our client.
Probes may be ordered separately except +5, +9 and +15 which are combined.
Global cases with IgH rearrangement will automatically reflex to the Plasma Cell Myeloma IgH Complex FISH Panel unless client has opted out.
Disease(s): Plasma cell myeloma, multiple myeloma
Note: Plasma cell enrichment will be performed on bone marrow or blood samples unless our client directs us otherwise. (Peripheral blood is not recommended as a screening specimen unless increased plasma cells are seen on blood smear.) Specimens should be received in our laboratory within 72 hours of collection. If enriched samples are insufficient to complete the whole panel, NeoGenomics will prioritize p53 testing unless directed otherwise by our client.
Test Code
LAB6075
Alias/See Also
Multiple Myeloma-MGUS, MM-MGUS FISH Panel
CPT Codes
88374x5 automated or 88377x5 manual without reflex; with reflex add 88374x4 automated or 88377x4 manual
Preferred Specimen
•Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable
•Peripheral Blood: Not recommended as a screening specimen unless increased plasma cells are seen on blood smear. 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
•Fresh, Unfixed Tissue: Tissue in RPMI
•Fluids: Equal parts RPMI to specimen volume
•Paraffin Block or Cut Slide: N/A
•Peripheral Blood: Not recommended as a screening specimen unless increased plasma cells are seen on blood smear. 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
•Fresh, Unfixed Tissue: Tissue in RPMI
•Fluids: Equal parts RPMI to specimen volume
•Paraffin Block or Cut Slide: N/A
Instructions
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.Specimens should be received in our laboratory within 72 hours of collection.
Methodology
FISH
Report Available
3-5 days. Add 3-5 days if reflexed.
Performing Laboratory
Neogenomics Laboratories
