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PDGFRA Rearrangement
MessageProbes: PDGFRA | CHIC2 | FIP1L1 (4q12) Disease(s): Chronic eosinophilic leukemia, MPN
Test Code
LAB6046
Alias/See Also
PDGFR Alpha Rearrangement
CPT Codes
88374x1 automated or 88377x1 manual.
Preferred Specimen
Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable Fresh, Unfixed Tissue: Tissue in RPMI Fluids: Equal parts RPMI to specimen volume. Paraffin block: Send paraffin block. Also send circled H&E slide for tech-only (required). Cut slides: H&E slide (required) plus 4 unstained slides cut at 4-5 microns. Circle H&E slide for tech-only.
Instructions
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Methodology
FISH
Report Available
3-5 days
Clinical Significance
FISH for FIP1L1-PDGFRA is generally found in chronic eosinophilic leukemia, but the presentation can be as acute myeloid leukemia, T-lymphoblastic lymphoma or both simultaneously. Detection of this abnormality predicts responsiveness to tyrosine kinase inhibitors. PDGFRA rearrangement is usually cryptic by routine cytogenetic analysis.
Performing Laboratory
Neogenomics Laboratories
