MPN FISH Panel

Message

Probes: PDGFRa, CHIC2, FIP1L1 (4q12) | PDGFRb (5q33) | FGFR1 (8p11) | BCR/ABL1 t(9;22) including ASS1 (9q34) | Probes may be ordered separately.
Disease(s): Myeloproliferative neoplasms

Test Code

LAB6069

Alias/See Also

Myeloprofilerative neoplasms

CPT Codes
88374x4 automated. Codes may differ if manual analysis is performed.

Preferred Specimen

•Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, Unfixed Tissue: Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block or Cut Slides: Not available.

Instructions

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

Methodology
FISH

Report Available

3-5 days

Clinical Significance

The MPN FISH panel is indicated in the diagnosis of myeloproliferative neoplasms with eosinophilia and as a guide to therapeutic selection. Patients with BCR-ABL, PDGFRA or PDGFRB rearrangements are responsive to tyrosine kinase inhibitors. There currently is no established TKI therapy for diseases with FGFR1 rearrangement, but some promising new therapies have been reported. If these FISH studies are negative, that does not exclude a myeloproliferative neoplasm and molecular studies for JAK2 and/or MPL mutations should also be considered in the work-up of a possible myeloproliferative neoplasm.

Performing Laboratory
Neogenomics Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.