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MDS Extended FISH Panel

Message
Probes: RPN1, MECOM (3q21, 3q26.2) | 5q-, -5 (5p15, 5q31, 5q33) | 7q-, -7 (Cen 7, 7q22, 7q31) | Trisomy 8 (Cen 8) | MLL (11q23) | ETV6 (12p13) | 17p- (TP53 17p13.1, NF1 17q11.2) | +19 (19p13.2, 19q13) | 20q- (20q12, 20qter)
Probes may be ordered separately except +8 and 20q- which are combined.
Disease(s): Myelodysplastic syndrome


Test Code
LAB6067


Alias/See Also
Myelodysplastic syndrome


CPT Codes
88374x8 automated. Codes may differ if manual analysis is performed.

Preferred Specimen
•Bone marrow aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, unfixed tissue: Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin block or cut slides: Not available.
Bone marrow aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, unfixed tissue: Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin block or cut slides: Not available.


Instructions
Refrigerate specimen. Do not freeze. Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.


Methodology
FISH

Report Available
3-5 days


Clinical Significance
The MDS Extended FISH Panel accommodates the 2012 Revised IPSS (IPSS-R) classification of five cytogenetic risk groups: very good, good, intermediate, poor, and very poor.


Performing Laboratory
Neogenomics Laboratories



The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.