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Low-Grade/Small B-Cell Lymphoma FISH Panel
MessageProbes: BCL6 (3q27) | CCND1/IgH t(11;14) IgH/BCL2 t(14;18) | MALT1 (18q21)
Probes may be ordered separately.
Disease(s): NHL, B-Cell Lymphoma, MCL, follicular lymphoma, MZL, MALT lymphoma
Probes may be ordered separately.
Disease(s): NHL, B-Cell Lymphoma, MCL, follicular lymphoma, MZL, MALT lymphoma
Test Code
LAB6066
Alias/See Also
Small B-Cell Lymphoma
CPT Codes
88374x4 automated. Codes may differ if manual analysis is performed.
Preferred Specimen
•Bone Marrow Aspirate: 1-2mL Sodium Heparin Tube. EDTA tube is acceptable
•Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
•Fresh, Unfixed Tissue: Tissue in RPMI
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only. Testing on this specimen type is not yet available for NY specimens. Cut Slide: H&E slide (required) plus 8 unstained slides cut at 4 microns for panel. Circle H&E for tech-only. Testing on this specimen type is not yet available for NY specimens.
•Peripheral Blood: 2-5mL Sodium Heparin Tube. EDTA tube is acceptable
•Fresh, Unfixed Tissue: Tissue in RPMI
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block: H&E slide (required) plus paraffin block. Circle H&E for tech-only. Testing on this specimen type is not yet available for NY specimens. Cut Slide: H&E slide (required) plus 8 unstained slides cut at 4 microns for panel. Circle H&E for tech-only. Testing on this specimen type is not yet available for NY specimens.
Instructions
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Methodology
FISH
Report Available
4 days for both unfixed and FFPE specimens
Clinical Significance
Significance:
This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas (such as large cell anaplastic and Burkitt lymphoma) are not a diagnostic consideration. BCL6 evaluation (included in this panel) can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma. Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is also within this category, but typically has a peripheral blood lymphocytosis and is better evaluated by the CLL FISH Panel or NeoTYPE™ CLL Profile.
This targeted panel is appropriate when clinical and morphologic evaluation is most suggestive of a low-grade/small B-cell lymphoma, and high-grade lymphomas (such as large cell anaplastic and Burkitt lymphoma) are not a diagnostic consideration. BCL6 evaluation (included in this panel) can provide further prognostic information in cases of follicular lymphoma since it can indicate a higher risk for transformation to aggressive lymphoma. Low-grade/small B-cell lymphomas include follicular lymphoma, mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL)/MALT lymphomas. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is also within this category, but typically has a peripheral blood lymphocytosis and is better evaluated by the CLL FISH Panel or NeoTYPE™ CLL Profile.
Performing Laboratory
Neogenomics Laboratories
