CLL FISH Analysis

Message

Probes: 6q- [SEC63 (6q21), MYB (6q23)] | ATM (11q22.3) | p53 (17p13.1) | Trisomy 12 (Cen 12) | 13q-/-13 (13q14, 13q34) | CCND1/IgH t(11;14) | Probes may be ordered separately (except 12 and 13 are tested together, and ATM is tested with p53).
Disease(s): Chronic lymphocytic leukemia
Note: This test was previously called CLL FISH Panel (non-New York). It is now New York state-approved and available to all clients.

Test Code

LAB4101

Alias/See Also

Chronic lymphocytic leukemia

CPT Codes
88374x4 automated. Codes may differ if manual analysis is performed.

Preferred Specimen

Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable. •Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable. •Fresh, Unfixed Tissue: Tissue in RPMI. •Fluids: Equal parts RPMI to specimen volume •Paraffin Block or Cut Slides: Not available.

Instructions

Use cold pack for transport, making sure cold pack is not in direct contact with specimen.

Transport Container

Green top tube (Sodium Heparin)

Methodology
FISH

Report Available

3-5 days

Clinical Significance

The CLL FISH panel is used for the detection of chromosome aberrations observed in chronic lymphocytic leukemia/small lymphocytic lymphoma, which are useful in prognosis and prediction of time to treatment in CLL patients when used in combination with other clinical and diagnostic findings. CCND1/IgH is used to rule out mantle cell leukemia/lymphoma.

Performing Laboratory
Neogenomics Laboratories

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.