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ALL Adult FISH Panel
MessageProbes: TCF3/PBX1 (E2A/PBX1) t(1;19) | Trisomy or Tetrasomy 4, 6, 10, 17 (Cen 4, Cen 6, Cen 10, Cen 17) | MYC (8q24) | BCR/ABL1/ASS1 t(9;22) | MLL (11q23) | IgH (14q32) |
Disease(s): Acute lymphoblastic (lymphocytic) leukemia (B-cell ALL), B lymphoblastic lymphoma (LBL), adult
Probes may be ordered separately except Centromeres 4 and 17 are paired, and Centromeres 6 and 10 are paired.
Note: STAT processing is available by request for BCR-ABL1. Note STAT along with MD contact name and phone number to receive STAT results.
Note: CDKN2A (p16) Deletion FISH is also available and may be ordered separately. See details on the Neogenomics website.
Disease(s): Acute lymphoblastic (lymphocytic) leukemia (B-cell ALL), B lymphoblastic lymphoma (LBL), adult
Probes may be ordered separately except Centromeres 4 and 17 are paired, and Centromeres 6 and 10 are paired.
Note: STAT processing is available by request for BCR-ABL1. Note STAT along with MD contact name and phone number to receive STAT results.
Note: CDKN2A (p16) Deletion FISH is also available and may be ordered separately. See details on the Neogenomics website.
Test Code
LAB6064
Alias/See Also
Acute lymphoblastic leukemia
CPT Codes
88374x7 automated. Codes may differ if manual analysis is performed.
Preferred Specimen
•Bone Marrow Aspirate: 1-2 mL sodium heparin tube. EDTA tube is acceptable.
•Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, Unfixed Tissue: Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block or Cut Slides: Not available.
•Peripheral Blood: 2-5 mL sodium heparin tube. EDTA tube is acceptable.
•Fresh, Unfixed Tissue: Tissue in RPMI.
•Fluids: Equal parts RPMI to specimen volume.
•Paraffin Block or Cut Slides: Not available.
Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Methodology
FISH
Report Available
3-5 days
Clinical Significance
The ALL Adult FISH Panel is used for the detection of recurrent chromosome abnormalities observed in adults with ALL of B-cell lineage and B lymphoblastic lymphoma (LBL). Identification of specific abnormalities helps predict disease aggressiveness and response to therapy. This panel differs from the ALL Pediatric FISH Panel in that this panel excludes probes for ETV6/RUNX1 t(12;21).
Performing Laboratory
Neogenomics Laboratories
