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High Sensitivity PNH Evaluation
MessageMarkers are CD14, CD15, CD24, CD45, CD59, CD64, CD235a (Glycophorin A), and FLAER. In validation studies, this assay was shown to detect RBC and granulocyte PNH clones with frequency down to 0.01%.
Test Code
LAB3825
Alias/See Also
High Sensitivity PNH Evaluation (Epic Procedure Catalog)
CPT Codes
88184x1, 88185x7, 88187x1
Preferred Specimen
Peripheral blood: 1-2 mL EDTA preferred. 1-2 mL minimum in sodium heparin tube or ACD (pale yellow, no gel separator) is acceptable. Please provide a recent CBC report. Bone marrow specimens are not acceptable.
Instructions
Specimens should be received at NeoGenomics within 48 hours from collection to assure sample integrity and acceptable cell viability. Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen.
Methodology
Flow Cytometry
Report Available
1 day
Clinical Significance
Useful for diagnosis of PNH (paroxysmal nocturnal hemoglobinuria) and monitoring response to therapy. Small PNH clones may also be identified in patients with aplastic anemia and MDS who may respond to immune modulation therapy. Also identifies patients at increased risk of developing overt PNH. This assay is consistent with International Clinical Cytometry Society (ICCS) Guidelines. NeoGenomics no longer performs PNH testing on bone marrow specimens.
Performing Laboratory
Neogenomics Laboratories
