SYPHILIS ANTIBODY IGG/IGM, CASCADING REFLEX

LAB1197

Syphilis Antibody Cascading Reflex

If Syphilis IgG/IgM CMIA result is reactive, then RPR Screen with Reflex to titer will be performed. If the RPR is reactive, a RPR titer will be reported. If RPR is non reactive, then TP-PA will be reported and performed.

7 mL Red Top Tube

4.0 mL

Grossly hemolyzed or contaminated  samples

Set Up: Monday - Friday; Report Available: 1 day

Non Reactive

The Architect Syphilis TP assay is a chemiluminescent microparticle immunoassay for the qualitative detection of (IgG/IgM) antibodies directed against Treponema Pallidum in serum. Syphilis is caused by infection with the bacterium Treponema pallidum (TP), which is transmitted by sexual contact or congenitally. The disease can present in different clinically defined stages (primary, secondary, latent, and tertiary); the latent phase is asymptomatic. Upon infection with TP, an immune response develops that is directed not only against antigens specific to TP but also antigens released during the TP-mediated cellular damage. Two types of tests have been developed as aids to diagnose syphilis, treponemal and nontreponemal. A positive treponemal test result is an indication for an acute, latent, or past infection with TP. Nontreponemal tests are especially valuable for monitoring disease activity and therapy response. It is common practice that reactive test results of either a treponemal or nontreponemal test are confirmed by a test of the complimentary test type to enhance diagnostic accuracy.