MONONUCLEOSIS SCREEN

Test Code

LAB482

Alias/See Also

MONOSPOT MONO HETEROPHILE ABS

CPT Codes
86308

Preferred Specimen

7 mL Red Top Tube

Minimum Volume

2.0 mL

Transport Temperature

Refrigerate specimen

Methodology
Lateral Flow

Setup Schedule

Set Up:Daily; Report Available:1 day

Reference Range

Negative

Clinical Significance

Infectious mononucleosis is an acute or subacute benign infectious lymphoproliferative disease that is, associated with the Epstein-Barr virus of Burkitts lymphoma. The disease is characterized by an increase in atypical lymphocytes in the circulation, by enlargement in the lymph nodes and spleen, by fever and by characteristic heterophile antibodies. Heterophil antibodies for sheep red cells are found in about 80-100% of patients with infectious mononucleosis. They are IgM 19S immunoglobulins, which can be demonstrated between the fourth and tenth day. Absence of sheep cell-agglutination antibodies does not exclude the diagnosis of infectious mononucleosis, but even high sheep cell titers are not diagnostic of infectious mononucleosis since they have been reported in other myelolymphoproliferative disorders such as leukemia, polycythemia vera, Hodgkins disease and others.

Performing Laboratory
GBMC Immunology

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.