CANCER ANTIGEN 125

Test Code

LAB155

Alias/See Also

CA125
OVARIAN CANCER ANTIGEN

CPT Codes
86304

Preferred Specimen

Green Top/Gel LiHep

Minimum Volume

2.0 mL

Transport Container

Li Heparin (GST)

Transport Temperature

Refrigerate specimen

Methodology
ECLIA

Setup Schedule

Set Up:Daily Report Available:1 day

Reference Range

Cancer antigen 125:

2.1 - 35.0 U/mL

Clinical Significance

Serum CA 125 assay values are useful for monitoring the course of disease in patients with invasive epithelial ovarian cancer. In a review of nine published studies, the overall correlation reported between CA 125 serum levels and the course of the disease was 87%. Persistently rising CA 125 assay values may be associated with malignant disease and poor response to therapy, whereas decreasing CA 125 assay values may indicate a favorable response to therapy. Elevations of CA 125 assay values have been reported in approximately 1-2% of healthy individuals, and in individuals with nonmalignant conditions such as cirrhosis, hepatitis, endometriosis, first trimester pregnancy, ovarian cysts, and pelvic inflammatory disease. Elevations of CA 125 assay values during the menstrual cycle have also been reported. Non-ovarian malignancies in which elevated CA 125 assay values have been reported include cervical, liver, pancreatic, lung, colon, stomach, biliary tract, uterine, fallopian tube, breast, and endometrial carcinomas. The CA 125 assay is not recommended as a screening procedure to detect cancer in the general population; however, use of the CA 125 assay as an aid in the management of ovarian cancer patients has been reported.

Performing Laboratory
GBMC Chemistry

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.