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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
GENTAMICIN-TROUGH
Test CodeLAB26
Alias/See Also
GENTAMYCIN, PRE
CPT Codes
80170
Preferred Specimen
7 mL Red Top Tube
Minimum Volume
0.3 mL
Instructions
Preferred: Patient in steady state Collect 1 hour prior to administration Collected 0-60 minutes prior to next dose.
Transport Container
Plain Red (7RD)
Methodology
Immunoturbinometric
Setup Schedule
Set Up:Daily Report Available:Routine 4 hr/ STAT 1hr
Reference Range
| GENTAMICIN-TROUGH | Therapeutic: 0.0 - 1.9 ug/mL Toxic >2.0 ug/mL |
Clinical Significance
Gentamicin is an aminoglycoside antibiotic that displays broad spectrum, high potency, anti-bacterial action for most susceptible organisms. At therapeutic serum concentrations ranging from 4 to 10 μg/mL (8.4 to 20.9 μmol/L), gentamicin is capable of inhibiting the growth of many gram positive cocci, especially penicillinase-producing staphylococci. At concentrations of 10 μg/mL (20.9 μmol/L), most strains of E coli, Proteus spp., Klebsiella, Aerobacter, Clostridium, Brucella spp., Salmonella, Serratia, and Shigella are inhibited. At concentrations ranging from 4 to 10 μg/mL (8.4 to 20.9 μmol/L), gentamicin displays activity against most strains of Pseudomonas aeruginosa. Because of these characteristics, gentamicin has been most successfully used in the treatment of serious infections, especially those caused by gram-negative bacilli. The therapeutic range of gentamicin should be measured at peak as well as trough concentrations. In patients with pre-existing renal damage or those to whom gentamicin has been administered for prolonged periods or in doses above the therapeutic range, hearing impairment and/or nephrotoxicity may develop. Therefore, monitoring of peak and trough gentamicin levels is critical in the prevention of these serious complications with the adjustment of dosage administration as indicated.
Performing Laboratory
GBMC Chemistry
