IMMUNOGLOBULIN IGM

Test Code

LAB72

CPT Codes
82784

Preferred Specimen

5.0 mL Gold SST

Minimum Volume

2.0 mL

Other Acceptable Specimens

7.0 mL Red Top Tube

Transport Container

SST

Transport Temperature

Refrigerated

Methodology
Immunoturbidimetric

Setup Schedule

Set Up:Daily Report Available:Same day

Reference Range

Age (Female/Male)	Reference Range
<1M	5-87 mg/dL
1M-2M	17-105 mg/dL
2M-3M	24-89 mg/dL
3M-6M	35-102 mg/dL
6M-1Y	43-173 mg/dL
1Y-2Y	48-168 mg/dL
2Y-3Y	22-159 mg/dL
3Y-8Y	43-207 mg/dL
8Y-10Y	52-242 mg/dL
>10Y	48-298 mg/dL

Clinical Significance

IgM exists primarily as a pentamer of the basic immunoglobulin structure with a J chain, a small glycoprotein. It is the largest immunoglobulin molecule (MW = 900,000), but makes up only 6% of the total immunoglobulins. It is the primary immune response and reacts rapidly. IgM is capable of activating complement, thus helping to kill bacteria. Increased polyclonal IgM levels are found in viral, bacterial, and parasitic infections, liver diseases, rheumatoid arthritis, scleroderma, cystic fibrosis, and heroin addiction. Monoclonal IgM is increased in Waldenstroms macroglobulinemia.2-5 Increased loss of IgM is found in protein-losing enteropathies and in burns. Decreased synthesis of IgM occurs in congenital and acquired immunodeficiency syndromes.

Performing Laboratory
GBMC Chemistry

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.