IMMUNOGLOBULIN IGG

Test Code

LAB71

CPT Codes
82784

Preferred Specimen

5.0 mL Gold SST

Minimum Volume

2.0 mL

Other Acceptable Specimens

7.0 mL Red Top Tube

Transport Temperature

Refrigerated

Methodology
Immunoturbidimetric

Setup Schedule

Set Up:Daily Report Available:Same day

Reference Range

Age (Female/Male)	Reference Range
<1M	251-906 mg/dL
1M-2M	206-601 mg/dL
2M-3M	176-581 mg/dL
3M-6M	215-704 mg/dL
6M-2Y	345-1213 mg/dL
2Y-3Y	441-1135 mg/dL
3Y-8Y	463-1280 mg/dL
8Y-10Y	608-1572 mg/dL
>10Y	622-1593 mg/dL

Clinical Significance

IgG molecules are monomers composed of two light chains (kappa and lambda) and two gamma heavy chains.1 Approximately 80% of serum immunoglobulin is IgG; its main task lies in defense against microorganisms, direct neutralization of toxins, and induction of complement fixation. IgG is the only immunoglobulin that can cross the placental barrier and provide passive immune protection for the fetus and newborn. This protection gradually catabolizes until the infants own immunological system begins to function at about six months of age. Near adult levels are reached by 18 months. Polyclonal IgG increases may be present in systemic lupus erythematosis, chronic liver diseases (infectious hepatitis and Laennecs cirrhosis), infectious diseases, and cystic fibrosis. Monoclonal IgG increases in IgG myeloma. Decreased synthesis of IgG is found in congenital and acquired immunodeficiency diseases and selective IgG subclass deficiencies, such as Bruton type agammaglobulinemia. Increased IgG loss is seen in protein-losing enteropathies, nephrotic syndrome, and through the skin from burns. Increased IgG metabolism is found in Wiskott-Aldrich syndrome, myotonic dystrophy, and with anti-immunoglobulin antibodies.

Performing Laboratory
GBMC Chemistry

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.