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| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
SALICYLATE
Test CodeLAB34
Alias/See Also
ASPIRIN
ASA
ASA
CPT Codes
80196
Preferred Specimen
7 mL red top tube
Minimum Volume
2.0 mL
Transport Temperature
Refrigerated
Methodology
Enzymatic Colorimetric
Setup Schedule
Set Up:Daily Report Available:1 day
Reference Range
| Analgesic: <100 mg/L Antipyretic: <100 mg/L Anti-inflammatory: 100 - 300 mg/L Critical value: >400 mg/L |
Clinical Significance
The salicylates are a group of compounds used as analgesics, antipyretics and anti-inflammatory agents. Acetylsalicylic Acid (aspirin), the most commonly used salicylate, and sodium salicylate are the principal compounds taken orally. The salicylate assay also detects diflunisal, a salicylic acid derivative with pharmacological properties similar to salicylate. Salicylates are readily available over-the-counter and most salicylate therapy is the result of patient self-medication. Chronic salicylate dosing generates a therapeutic level of approximately 60 mg/L and monitoring is not required. In rheumatoid arthritis therapy, however, large doses of salicylate (3-5 g/day) are administered, and monitoring serum levels is desirable to maintain a therapeutic range of 150-300 mg/L. Serum concentrations greater than 300 mg/L are considered toxic. Because salicylates are widely available, they are frequently seen in overdose cases. Salicylate poisoning is seldom fatal, but causes side effects ranging from nausea, vomiting and tinnitus to fever, lethargy and coma. Proper management of salicylate poisoning requires monitoring the patient's serum level. The drug concentration determines steps toward detoxification.
Performing Laboratory
GBMC Chemistry
