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MPL Mutation Analysis
MessageBi-directional sequencing of exon 10 of the MPL gene to detect all possible mutations at the W515 and S505 codons, and other mutations throughout the exon. Testing is performed on plasma for increased sensitivity whenever possible. This test may be ordere
Test Code
LAB6035
Alias/See Also
Myeloproliferative Leukemia
CPT Codes
81402x1
Preferred Specimen
•Peripheral Blood: 5 mL EDTA tube
•Bone Marrow: 2 mL EDTA tube
•Bone Marrow: 2 mL EDTA tube
Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Ship same day as drawn whenever possible; specimens <72 hours old preferred.
Methodology
Molecular
Report Available
10 days
Clinical Significance
MPL W515 mutations are present in JAK2-negative patients with primary myelofibrosis (PMF) or essential thrombocythemia (ET) at a frequency of approximately 1-5%, respectively. The S505 mutation is usually detected in patients with familial essential thrombocythemia. Mutation analysis helps differentiate reactive conditions from MPNs.
Performing Laboratory
Neogenomics Laboratories
