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B-Cell Rearrangement-Molecular
MessageDetection of clonal IgH gene rearragements by PCR of IgH framework regions 1, 2, 3 and joining regions. In addition, Ig Kappa gene rearrangement analysis is performed using specific oligonucleotides recognizing the Vk, intragenic and Jk regions. Testing is approved for specimens from the state of New York.
Test Code
LAB4678
Alias/See Also
B-Cell Translocations
CPT Codes
81479x1
Preferred Specimen
Peripheral blood: 5 mL in EDTA tube.
Bone marrow: 2 mL in EDTA tube.
FFPE tissue: Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5-10 unstained slides cut at 5 or more microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.
Fresh tissue: Two pieces minimum, 0.2 cm3 in RPMI.
Instructions
Refrigerate fresh tissue until shipping. For all specimens, use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Transport Temperature
For all specimens, use cold pack for transport.
Methodology
Molecular
Report Available
7 days
Clinical Significance
Detects monoclonal B-cell immunoglobulin gene rearrangement. Interpret in clinical context for diagnosis of leukemia, lymphoma, and plasma cell dyscrasia.
Performing Laboratory
Neogenomics Laboratories
