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Chromosome Analysis, Amniotic Fluid
Test CodePhysician Attestation of Informed Consent
Preferred Specimen
Minimum Volume
Instructions
30 mL is preferred if other testing, e.g. microarray, FISH is ordered.
Ship at room temperature. Do not Freeze.
Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab).
Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Transport Temperature
Specimen Stability
Refrigerated: Acceptable
Frozen: Unacceptable
Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Methodology
Culture • Karyotype • Microscopy
Setup Schedule
Clinical Significance
This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.