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Prostate Health Index (phi)
Test Code38427
CPT Codes
84153, 84154<br>Restricted Client Code
Includes
When PSA, Total is between 4-10 ng/mL it will reflex to the P2PSA (CPT code: 86316). With the PSA, Free and PSA, Total and the P2PSA results the Prostate Health Index (phi) will be calculated.
Preferred Specimen
3 mL serum
Minimum Volume
0.9 mL
Instructions
Specimens for [-2]proPSA testing should be drawn prior to such prostatic manipulations as digital rectal examination (DRE), prostatic massage, transrectal ultrasound (TRUS), and prostatic biopsy. DRE may cause a transient increase in [-2]proPSA, fPSA, and PSA.19
Transport Temperature
Frozen
Specimen Stability
Room temperature: 72 hours
Refrigerated: 72 hours
Frozen: 5 months
Refrigerated: 72 hours
Frozen: 5 months
Methodology
Chemiluminescent Immunoassay
Setup Schedule
Set up: Tues-Sat; Report available: Same day
Clinical Significance
phi testing significantly impacted the physician’s biopsy decision for men with tPSA in the 4–10 ng/ml range and non-suspicious DRE findings. Appropriate utilization of phi resulted in a significant reduction in biopsy procedures performed compared to historical patients seen by the same participating urologists who would have met enrollment eligibility but did not receive a phi test.
