17-Hydroxyprogesterone Response to ACTH Stimulation [17682X]

Test Code

CPT Codes
83498 (x2)

17-Hydroxyprogesterone, Baseline
17-Hydroxyprogesterone, 60 Minutes

Preferred Specimen
1 mL (each specimen) collected in a red-top tube (no gel)

Minimum Volume
0.5 mL (each specimen)

Other Acceptable Specimens
Plasma collected in: EDTA (lavender-top), EDTA (royal blue-top), sodium heparin (green-top) or lithium heparin (green-top) tube

Draw baseline specimen. Draw another specimen 60 minutes after stimulation. 
Draw blood in a red-top tube (no gel). Separate serum after clotting. Ship serum refrigerated or frozen. Do not submit glass tubes.

Transport Container
Plastic screw-cap vial(s)

Transport Temperature

Refrigerated (cold packs)

Specimen Stability
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 2 years

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Serum Separator Tubes (SST®)

Chromatography/Mass Spectrometry

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule
Set up: Sun-Fri; Report available: 3-6 days

Reference Range
See Laboratory Report

Clinical Significance
17-hydroxyprogesterone is elevated in patients with congenital adrenal hyperplasia (CAH). CAH is a group of autosomal recessive diseases characterized by a deficiency of cortisol and an excess of ACTH concentration. 17-hydroxyprogesterone is also useful in monitoring cortisol replacement therapy and in evaluating infertility and adrenal and ovarian neoplasms.

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.