| A B C D E F G H I J K L M N O P Q R S T U V W X Y Z # |
Adiponectin
Test CodeLAB21081
Quest Code
15060
CPT Codes
83520
Preferred Specimen
1 mL serum
Patient Preparation
Overnight fasting required
Minimum Volume
0.5 mL
Instructions
1. Collect and label sample according to standard protocols.
2. Gently invert tube 5 times immediately after draw. Do Not Shake.
3. Allow blood to clot 30 minutes.
4. Centrifuge for 10 minutes.
5. Store serum at 2-8° C after collection and ship the same day.
2. Gently invert tube 5 times immediately after draw. Do Not Shake.
3. Allow blood to clot 30 minutes.
4. Centrifuge for 10 minutes.
5. Store serum at 2-8° C after collection and ship the same day.
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
Room temperature: 4 days
Refrigerated: 14 days
Frozen: 28 days
Refrigerated: 14 days
Frozen: 28 days
Methodology
Immunoturbidimetry Assay
FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics Cardiometabolic Center of Excellence at Cleveland HeartLab. It has not been cleared or approved by the U.S. Food and Drug Administration. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Setup Schedule
Set up: Tues, Thurs, Sat; Report available: 2-4 days
Reference Range
| Male | |
| BMI <25 kg/m2 | 2.3-15.2 ug/mL |
| BMI 25-30 kg/m2 | 2.1-16.7 ug/mL |
| BMI >30 kg/m2 | 2.2-12.9 ug/mL |
| Female | |
| BMI <25 kg/m2 | 2.9-30.4 ug/mL |
| BMI 25-30 kg/m2 | 2.5-26.8 ug/mL |
| BMI >30 kg/m2 | 3.9-21.8 ug/mL |
Clinical Significance
Adipocytes (fat cells) express a variety of proteins that function in the homeostatic control of glucose and lipid metabolism. Insulin regulates the translocation and secretion of many of these proteins in response to changes in energy balance. Adiponectin is a protein whose secretion from adipocytes is enhanced by insulin stimulation. It has been suggested that the development of non-insulin dependent (Type II) diabetes may involve dysregulation of adiponectin secretion. In support of the link between obesity and Type II diabetes, it has been shown that decreased expression of adiponectin correlates with insulin resistance, and that adiponectin appears to be a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
• Individuals with low adiponectin levels have a 3X greater risk of developing metabolic syndrome [1].
• Men with two or more risk factors for metabolic syndrome and high adiponectin levels are half as likely to develop metabolic syndrome as men with low adiponectin levels [2].
• Individuals with low levels of adiponectin are up to 9X as likely to develop type 2 diabetes [3].
• Individuals with low adiponectin levels have a 2X increase in the prevalence of CAD [4].
• Adiponectin levels in the blood can be increased by thiazolidinediones, such as pioglitazone [5].
References:
1. Chen SJ et al. PLoS ONE. 2012; 7: e45693.
2. Kotooka N et al. Int J Cardiol. 2012 Nov 26. pii: S0167-5273(12)01441-6. doi:10.1016/j.ijcard.2012.10.066. [Epub ahead of print].
3. Daimon M et al. Diabetes Care. 2003; 26: 2015-2020.
4. Kumada M et al. Arterioscler Thromb Vasc Biol. 2003; 23: 35-39.
5. McCoy RG et al. Mayo Clin Proc. 2012; 87: 561-570.
• Individuals with low adiponectin levels have a 3X greater risk of developing metabolic syndrome [1].
• Men with two or more risk factors for metabolic syndrome and high adiponectin levels are half as likely to develop metabolic syndrome as men with low adiponectin levels [2].
• Individuals with low levels of adiponectin are up to 9X as likely to develop type 2 diabetes [3].
• Individuals with low adiponectin levels have a 2X increase in the prevalence of CAD [4].
• Adiponectin levels in the blood can be increased by thiazolidinediones, such as pioglitazone [5].
References:
1. Chen SJ et al. PLoS ONE. 2012; 7: e45693.
2. Kotooka N et al. Int J Cardiol. 2012 Nov 26. pii: S0167-5273(12)01441-6. doi:10.1016/j.ijcard.2012.10.066. [Epub ahead of print].
3. Daimon M et al. Diabetes Care. 2003; 26: 2015-2020.
4. Kumada M et al. Arterioscler Thromb Vasc Biol. 2003; 23: 35-39.
5. McCoy RG et al. Mayo Clin Proc. 2012; 87: 561-570.
Performing Laboratory
Cleveland HeartLab, Inc
6701 Carnegie Avenue Suite 500
Cleveland, OH 44103-4623
