Advanced Lipid Panel with Inflammation, Cardio IQ®

Test Code

LAB6267

Quest Code

94220

CPT Codes
80061, 83704, 82172, 83695, 86141, 83698

Includes

Cardio IQ® Cholesterol, Total
Cardio IQ® HDL Cholesterol
Cardio IQ® Triglycerides
Cardio IQ® Non-HDL and Calculated Components
Cardio IQ® Lipoprotein Fractionation, Ion Mobility
Cardio IQ® Apolipoprotein B
Cardio IQ® Lipoprotein (a)
Cardio IQ® hs-CRP
Cardio IQ® Lp-PLA2 Activity

If Triglyceride is >400 mg/dL, then Cardio IQ® Direct LDL will be performed at an additional charge (CPT code(s): 83721).
If Triglyceride is extremely elevated, > 1293 mg/dL, this causes interference in the Cardio IQ(R) Direct LDL assay, therefore this test cannot be added.

Preferred Specimen

5 mL serum and 1 mL serum

Patient Preparation
If a cholesterol measurement is to be performed along with triglycerides, but not part of a lipid panel, then the patient should be fasting 0-12 hours prior to collection. If the cholesterol is ordered as part of a lipid panel, then a fasting sample is not required.

Minimum Volume

2.75 mL and 0.25 mL

Instructions

The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been...determined to interfere with assays for...Cholesterol, Uric Acid" where "NAC interference may lead to falsely low results." According to Beckman Coulter, the NAC interference should be insignificant by 12 hours after completion of the initial loading dose of an IV infusion treatment regimen consisting of an initial loading dose of 150 mg/kg administered over 1 hr, a second dose of 50 mg/kg administered over 4 hrs and a third dose of 100 mg/kg administered over 16 hrs.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

Room temperature: 24 hours
Refrigerated: 7 days
Frozen: 28 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Moderate to grossly lipemic • Icteric

Methodology
Enzymatic • Immunoassay (IA) • Immunoturbidimetric Assay • Ion Mobility • Nephelometry • Spectrophotometry (SP)

FDA Status
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Setup Schedule

Set up: Mon-Sat; Report available: 3-6 days

Reference Range

See Laboratory Report

Clinical Significance

The 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommend matching the intensity of statin treatment with the absolute risk of cardiovascular events. However, the standard lipid panel alone does not provide a complete assessment of absolute risk of CVD. Adding advanced CVD markers (ion mobility, apob, lp(a), hs crp and lppla2) in addition to the lipid panel will improve assessment of the CVD risk.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92675-2042

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.