Antiphospholipid Syndrome Diagnostic Panel

Test Code

LAB6004

Quest Code

19872

Alias/See Also

APSDP

CPT Codes
86147 (x3), 86146 (x3), 85730, 85613

Includes

Cardiolipin Antibodies (IgA, IgG, IgM)
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM)
Lupus Anticoagulant Evaluation with Reflex (PTT-LA and dRVVT with Reflex Confirmations)

If PTT-LA Screen is prolonged (>40 seconds), then Hexagonal Phase Confirm is performed at an additional charge (CPT code(s): 85598).
If Hexagonal Phase Confirm is positive or weakly positive, then Thrombin Clotting Time will be performed at an additional charge (CPT code(s): 85670).
If dRVVT Screen is prolonged (>45 seconds), then dRVVT Confirmation will be performed at an additional charge (CPT code(s): 85597).
If dRVVT Confirm is positive, then dRVVT 1:1 Mix will be performed at an additional charge (CPT code(s): 85613).

Preferred Specimen

3 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

2 mL

Instructions

Centrifuge light blue-top tube 15 minutes at approximately 1500 g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis • Grossly lipemic • Received room temperature • Received refrigerated • Serum

Methodology
Immunoassay (IA) • Photo-Optical Clot Detection

Setup Schedule

See individual assays

Reference Range

See individual tests

Clinical Significance

This assay may be useful in supporting or ruling out a diagnosis of antiphospholipid syndrome.

Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.