Thyroglobulin, Tumor Marker - Serum (To Mayo Direct)

Test Code

LAB6129

Alias/See Also

THYRM, HTG2, 83069, LOINC: 3013-0

CPT Codes
84432

Includes

Thyroglobulin Antibody,
Thyroglobulin, Tumor Marker,
Thyroglobulin Interpretation

Preferred Specimen

2 mL Serum
Collection Container/Tube: Red top No SST

Patient Preparation
Patient Preparation: For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Minimum Volume

1 mL

Instructions

Collection Instructions: Red-top tubes should be centrifuged and aliquot serum into plastic tube.

Transport Container

Plastic screw-top aliquot tube

Transport Temperature

Refrigerated

Specimen Stability

Refrigerated (preferred) 7 days
Frozen 30 days

Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)

Hemolysis or Icterus: Mild OK; Gross reject
Lipemia OK

Methodology

Immunoenzymatic Assay

Setup Schedule

Mayo-Rochester: Monday through Friday 6 a.m. - 12 a.m., Saturday 6 a.m. - 6 p.m., Maximum time in Lab: 3 Days

Report Available

7 Days

Limitations

It has been determined that the presence of anti-thyroglobulin autoantibodies (TgAb), in serum can lead to underestimation of Tg concentration by immunometric methods. When TgAb are present in samples with detectable Tg, the Tg values may be underestimated by up to 60% in immunoassays. In addition, approximately 20% of specimens containing TgAb which are negative for Tg by immunoassay tested positive by LC-MS/MS. Therefore, measuring of Tg by mass spectrometry is the preferred method in TgAb positive patients.

Reference Range

THYROGLOBULIN, TUMOR MARKER: Athyrotic: <0.1 ng/mL, Intact thyroid < or =33 ng/mL
THYROGLOBULIN ANTIBODY: < 1.8 IU/mL (Note: values less then 1.8 will be reported as <1.8 IU/mL)
Refer to Mayo HTG2 link below for additional information.

Clinical Significance

Follow-up of patients with differentiated thyroid cancers after thyroidectomy and radioactive iodine ablation

Performing Laboratory
Mayo Clinic Laboratories

Additional Information
MayoMedicalLaboratories_HTG2_Link

The CPT Codes provided in this document are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed. Any Profile/panel component may be ordered separately. Reflex tests are performed at an additional charge.