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Hypercoagulable Profile
Message
Hypercoagulable profile is sent to QUEST reference lab for testing.
Test Code
LAB6035
Alias/See Also
HCOAG
Includes
LUPAE = Lupus Anticoagulant Evaluation
CARLN = Cardiolipin Abs G, A, M
FVL5 = Factor V Leiden Mutation
PROC = Protein C Antigen
PROS = Protein S, Total Antigen
ANT3A = Antithrombin III Activity
20210 = Prothrombin (Factor II)
F8C = Coag Factor VIII Activity
CARLN = Cardiolipin Abs G, A, M
FVL5 = Factor V Leiden Mutation
PROC = Protein C Antigen
PROS = Protein S, Total Antigen
ANT3A = Antithrombin III Activity
20210 = Prothrombin (Factor II)
F8C = Coag Factor VIII Activity
Preferred Specimen
LUPAE: 3 mL plasma collected in a 3.2% sodium citrate (light blue-top) tube
CARLN: 1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube
20210: 5 mL whole blood collected in an EDTA (lavender-top) tube
FVL5: 5 mL whole blood collected in an EDTA (lavender-top) tube
PROC: 1 mL frozen plasma collected in 3.2% sodium citrate (light blue-top) tube
PROS: 1 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube
Instructions -Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times.
Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to
avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma
into a new plastic vial(s). Freeze immediately and transport on dry ice.
ANT3A: 1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube
F8C: 1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube
Instructions Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within
60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer
and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial.
Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.
Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate
formation and falsely low Factor VIII and von Willebrand Factor studies.
CARLN: 1 mL citrated plasma collected in a 3.2% sodium citrate (light blue-top) tube
20210: 5 mL whole blood collected in an EDTA (lavender-top) tube
FVL5: 5 mL whole blood collected in an EDTA (lavender-top) tube
PROC: 1 mL frozen plasma collected in 3.2% sodium citrate (light blue-top) tube
PROS: 1 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube
Instructions -Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times.
Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to
avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma
into a new plastic vial(s). Freeze immediately and transport on dry ice.
ANT3A: 1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube
F8C: 1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube
Instructions Platelet-poor plasma: Centrifuge light blue-top tube for 15 minutes at approximately 1500 g within
60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer
and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial.
Plasma must be free of platelets (<10,000/mcL). Freeze immediately and ship on dry ice.
Note: Storage of whole blood at refrigerated temperatures prior to processing may lead to cryoprecipitate
formation and falsely low Factor VIII and von Willebrand Factor studies.
Methodology
See individual test information:
Performing Laboratory
Quest Diagnostics Nichols Institute
33608 Ortega Highway
San Juan Capistrano, CA 92690-6130
