Celiac Disease Panel

LAB821

19955

CELP 

Tissue Transglutaminase (tTG) Antibody (IgA)
IgA (Immunoglobulin A)

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86231).
If Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is less than the lower limit of the reference range, based on age, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).

5 mL serum

1 mL

Refrigerated (cold packs)

Room temperature: 72 hours
Refrigerated: 7 days
Frozen: 21 days

Gross hemolysis • Grossly lipemic

See individual assays

(tTG) Antibody, (IgA)

<15 U/mL		No antibody detected
≥15 U/mL		Antibody detected

IgA, Serum

Cord Blood		1-3 mg/dL
1-28 days		2-40 mg/dL
1-3 months		3-40 mg/dL
4-6 months		7-47 mg/dL
7-11 months		12-53 mg/dL
1 year		20-73 mg/dL
2 years		20-99 mg/dL
3-5 years		22-140 mg/dL
6-8 years		31-180 mg/dL
9-11 years		33-200 mg/dL
12-16 years		36-220 mg/dL
17-60 years		47-310 mg/dL
≥61 years		70-320 mg/dL

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.