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Unfractionated Heparin Anti-Xa
Test CodeLAB6130
Alias/See Also
UFHEP
Heparin Assay
Heparin Assay
CPT Codes
85520
Includes
Unfractionated heparin (UFH) levels in IU/mL
Instructions
Routine venipuncture; Collect one 2.7ml Blue top (sodium citrate) 90% of tube must be filled. Do not use syringe for collection.
Specimen Stability
Room temperature, stable for 2 hours
Reject Criteria (Eg, hemolysis? Lipemia? Thaw/Other?)
Tube <90% full; visible hemolysis; clotted specimen; improperly labeled specimen, specimen >2 hours at room temperature; Failure to follow proper collection and handling instructions.
Methodology
Quantitative Colorimetric assay
Setup Schedule
Daily
Report Available
Inpatient STAT: 1 hour
Reference Range
UFHEP: 0.30-0.70 IU/mL
Clinical Significance
Unfractionated heparin (UFH)/Low molecular weight heparin (LMWH) therapy is a reliable measurement for monitoring heparin therapy, the Heparin Anti-Xa Assay demonstrates more rapid achievement of anticoagulation goals, with fewer blood draws and dosage adjustments. The result is lower incidence of bleeding and recurrence of thromboembolism.
For monitoring LMWH, the anti-Xa assay plays an essential role since it is the only assay offered for this purpose, since LMWH has minimal effect on PTT. Furthermore, the anti-Xa assay is the most accurate methodology for monitoring UH, especially in the presence of a circulating inhibitor or when the baseline PTT is already prolonged (as in factor XII deficiency).
For monitoring LMWH, the anti-Xa assay plays an essential role since it is the only assay offered for this purpose, since LMWH has minimal effect on PTT. Furthermore, the anti-Xa assay is the most accurate methodology for monitoring UH, especially in the presence of a circulating inhibitor or when the baseline PTT is already prolonged (as in factor XII deficiency).
Additional Information
HyperCoagulable Testing
